Article
[Lewis-x, a sugar chain structure, suppresses the epileptic seizure in El mouse].
Seishin shinkeigaku zasshi = Psychiatria et neurologia Japonica - 1 Jan 1995
Masuda Y
Abstract excerpt
El mouse is a mutant strain with genetic epileptogenicity. Epileptic convulsion of El mouse has been shown to be related to metabolical and structural abnormalities in the hippocampal neuron. Gamma-globulin purified from the human serum has a marked anti-convulsive effect in El mouse. Human IgG, 80% of the gamma-globulin, has the reactivity indicating the presence of Lewis-x structure in the sugar chain. In the...
Topics
- Animals
- Dose-Response Relationship, Drug
- Epilepsy
- Genetic Predisposition to Disease
- Humans
- Mice
- Mice, Mutant Strains
- Oligosaccharides
- P-Selectin
- Platelet-Derived Growth Factor
- Sialyl Lewis X Antigen