Article
Chloroquine dissociation of antigen-antibody complexes. A new technique for typing red blood cells with a positive direct antiglobulin test.
Transfusion - 1 Jan 2000
Edwards J M, Moulds J J, Judd W J
Abstract excerpt
We have investigated a method using the quinoline derivative chloroquine diphosphate (200 mg/ml, pH 5.0) to dissociate antibody without denaturing red blood cell antigens. All samples treated with chloroquine diphosphate demonstrated some dissociation of the coating immunoglobulin, and in most ca...
Topics
- ABO Blood-Group System
- Antigen-Antibody Complex
- Blood Group Antigens
- Blood Grouping and Crossmatching
- Chloroquine
- Coombs Test
- Humans
- Hydrogen-Ion Concentration
- Immunologic Techniques
- Kell Blood-Group System
- Phenotype