Article
Formal genetics of isoniazid metabolism in man.
Clinical pharmacokinetics - 1 Jan 2000
Iselius L, Evans D A
Abstract excerpt
Complex segregation analysis of the isoniazid inactivator phenotype has shown the existence of a recessive gene and a multifactorial background. The phenotype is also influenced by age, sex and weight. The relevance of these findings to the grouping of individuals into slow and rapid inactivators is stressed.
Topics
- Acetylation
- Female
- Genes, Recessive
- Humans
- Isoniazid
- Male
- Models, Genetic
- Phenotype