Bronchial reactivity and small airway dysfunction in subjects with intermediate alpha 1-antitrypsin deficiency.

Article

Bronchial reactivity and small airway dysfunction in subjects with intermediate alpha 1-antitrypsin deficiency.

Bulletin europeen de physiopathologie respiratoire - 1 Jan 2000

Groth S, Lindell S E, Kabiraj M U, Bülow K, Arborelius M, Simonsson B G

Abstract excerpt

Lesions in small airways may cause increased central deposition of inhaled aerosol. This may enhance airway constriction following methacholine (MCh) challenge. Heterozygous alpha 1-antitrypsin deficiency (PiMZ) and smoking may both act on the lung parenchyma and may also influence small airways....

Topics

Airway Resistance
Bronchi
Humans
Male
Methacholine Compounds
Middle Aged
Phenotype
Respiratory Function Tests
Smoking
alpha 1-Antitrypsin Deficiency

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