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Article

Studies on tolerance development in inbred and heterogeneous stock National Institutes of Health rats.

Alcoholism, clinical and experimental research - 1 Jan 2000

Tabakoff B, Culp S G

Abstract excerpt

The rate of development of environment-independent tolerance was assessed in seven inbred strains of rats, in randomly bred Sprague-Dawley rats, and in the heterogeneous stock (HS) animals developed from the inbred strains. The results demonstrated significant differences in rates of tolerance development between the various groups of inbred animals. A relationship between the initial sensitivity of an animal to...

Topics

Alcoholism
Animals
Body Temperature Regulation
Crosses, Genetic
Disease Models, Animal
Drug Tolerance
Ethanol
Humans
Male
Metabolic Clearance Rate
Phenotype
Rats

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Rats, Inbred Strains

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Identifiers

PMID: 6391264
DOI: 10.1111/j.1530-0277.1984.tb05711.x

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-6391264-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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