Article
Lack of mutagenicity to S. typhimurium of neopentyl bromide and pentaerythrityl tetrachloride: relation to chemical structure.
Mutation research - 1 Jan 2000
Ashby J, Callander R D, Gilman D
Abstract excerpt
Neopentyl bromide and pentaerythrityl tetrachloride were shown here to be non-mutagenic to 7 strains of Salmonella typhimurium. These inactivities are reflected in the inability of either compound to produce a colour reaction in the chemical alkylation test of Epstein (4-nitrobenzylpyridine, NBP). It is suggested that the lack of biological reactivity of these two alkyl halides is due to steric crowding of the...
Topics
- Chemical Phenomena
- Chemistry
- Hydrocarbons, Brominated
- Hydrocarbons, Chlorinated
- Mutagenicity Tests
- Mutagens
- Mutation
- Salmonella typhimurium
- Structure-Activity Relationship