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Article

Intraspecific nucleotide sequence variability surrounding the origin of replication in human mitochondrial DNA.

Gene - 1 Jan 2000

Greenberg B D, Newbold J E, Sugino A

Abstract excerpt

We have cloned the major noncoding region of human mitochondrial DNA (mtDNA) from 11 human placentas. Partial nucleotide sequences of five of these clones have been determined and they share a maximum of 900 bp around the origin of H-strand replication. Alignment of these sequences with others previously determined has revealed a striking pattern of nucleotide substitutions and insertion/deletion events. The...

Topics

Amino Acid Sequence
Base Sequence
Cloning, Molecular
DNA Replication
DNA Restriction Enzymes
DNA, Mitochondrial
Female
Genetic Variation
Humans
Placenta
Polymorphism, Genetic

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Pregnancy

Protein Biosynthesis

Racial Groups

Source

Identifiers

PMID: 6301949
DOI: 10.1016/0378-1119(83)90145-2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-6301949-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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