Article
Coexistence of rheumatoid arthritis in married couples: a search for etiological factors.
The Journal of rheumatology - 1 Jan 2000
Schweiger F, Bell D A, Little A H
Abstract excerpt
Epstein-Barr virus (EBV) and the genetic marker HLA-DR4 both appear to play a role in the etiology of rheumatoid arthritis (RA). Antibodies to viral capsid antigen and the early antigen complex of the EB virus as well as the HLA phenotype were studied in 6 families. Both spouses had classical or definite RA but none of their offspring, all adult, had any evidence of RA. At least 1 spouse of each couple had DR4...
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