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Article

Coexistence of rheumatoid arthritis in married couples: a search for etiological factors.

The Journal of rheumatology - 1 Jan 2000

Schweiger F, Bell D A, Little A H

Abstract excerpt

Epstein-Barr virus (EBV) and the genetic marker HLA-DR4 both appear to play a role in the etiology of rheumatoid arthritis (RA). Antibodies to viral capsid antigen and the early antigen complex of the EB virus as well as the HLA phenotype were studied in 6 families. Both spouses had classical or definite RA but none of their offspring, all adult, had any evidence of RA. At least 1 spouse of each couple had DR4...

Topics

Adult
Aged
Antibodies
Arthritis, Rheumatoid
Female
HLA Antigens
HLA-DR4 Antigen
Herpesvirus 4, Human
Histocompatibility Antigens Class II
Humans
Male
Marriage

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Middle Aged

Pedigree

Phenotype

Source

Identifiers

PMID: 6270332

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-6270332-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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