Article
The biology of malignant gliomas--a comprehensive survey.
Clinical neuropathology - 1 Jan 2000
McComb R D, Bigner D D
Abstract excerpt
Malignant gliomas constitute a morphologically diverse group of neoplasms that respond poorly to therapy. The median survival of patients with glioblastoma multiforme, the most common malignant glioma, is only 11 months. Several factors influence the therapeutic resistance of malignant gliomas, including tumor heterogeneity, local invasion, and non-uniform vascular permeability to therapeutic agents. Malignant...
Topics
- Antibodies, Monoclonal
- Antigens, Neoplasm
- Brain Neoplasms
- DNA, Neoplasm
- Fibronectins
- Genotype
- Glial Fibrillary Acidic Protein
- Glioblastoma
- Glioma
- Humans
- Intermediate Filament Proteins
- Neovascularization, Pathologic