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Article

A haemoglobin switching activity modulates hereditary persistence of fetal haemoglobin.

Nature - 1 Jan 2000

Papayannopoulou T, Tatsis B, Kurachi S, Nakamoto B, Stamatoyannopoulos G

Abstract excerpt

During human development there is a switch from fetal to adult haemoglobin formation, reflecting the differential expression of fetal (G gamma and A gamma) and adult (beta and delta) globin genes. Mutations that inhibit this switch produce variants of the syndrome of hereditary persistence of fetal haemoglobin (HPFH). Adult heterozygotes for these mutants produce 15-30% fetal haemoglobin (HbF) in their red cells....

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PMID: 6201748
DOI: 10.1038/309071a0

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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