Article
A haemoglobin switching activity modulates hereditary persistence of fetal haemoglobin.
Nature - 1 Jan 2000
Papayannopoulou T, Tatsis B, Kurachi S, Nakamoto B, Stamatoyannopoulos G
Abstract excerpt
During human development there is a switch from fetal to adult haemoglobin formation, reflecting the differential expression of fetal (G gamma and A gamma) and adult (beta and delta) globin genes. Mutations that inhibit this switch produce variants of the syndrome of hereditary persistence of fet...
Topics
- Adult
- Cells, Cultured
- Chromosome Deletion
- Clone Cells
- Erythrocytes
- Fetal Hemoglobin
- Genes
- Globins
- Hemoglobin A
- Hemoglobinopathies
- Heterozygote
- Humans
- Infant, Newborn
- Mutation
- Phenotype