TOR-NOT4 signalling couples translation to co-translational quality control in plants.

doi:10.1038/s41467-026-77200-0

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Article

TOR-NOT4 signalling couples translation to co-translational quality control in plants.

Nature communications - 24 Aug 2026

Schwarze Maximillian A, Osborne Rory, Raffeiner Margot, González-Fuente Manuel, Kanali Anastasia, Bailey Mark, Etherington Ross D, Zhou Lina, Üstün Suayib, Gibbs Daniel J

Abstract excerpt

Protein synthesis must be tightly coordinated with quality control to prevent proteotoxic stress, yet the mechanisms underlying co-translational surveillance in plants, and how these are aligned with translational output, remain poorly understood. Here, we identify three NOT4-like E3 ubiquitin ligases in Arabidopsis thaliana as regulators of co-translational protein quality control and uncover a functional link...

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Topics

Arabidopsis
Arabidopsis Proteins
Signal Transduction
Protein Biosynthesis
Gene Expression Regulation, Plant

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Pseudomonas syringae

Ubiquitin-Protein Ligases

Proteasome Endopeptidase Complex

TOR Serine-Threonine Kinases

Proteotoxic Stress

Mutation

Plant Diseases

Phosphatidylinositol 3-Kinases

Source

Open in PubMed Open full text

Identifiers

PMID: 42773122
DOI: 10.1038/s41467-026-77200-0
PMCID: PMC13598129

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