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Article

Connective tissue and genetics in the pathogenesis of rectal prolapse: A scoping review.

Colorectal disease : the official journal of the Association of Coloproctology of Great Britain and Ireland - 1 Sept 2026

Davenport Matthew, O'Connor Alexander, Newman William G, Morris Andrew P, Sharma Abhiram, Faulkner Gemma, Vasant Dipesh H, McLaughlin John, Kiff Edward, Telford Karen

Abstract excerpt

AIM: Rectal prolapse can occur in individuals who lack the established risk factors (constipation, obstetric trauma and advanced age). A recognised association with hereditary connective tissue diseases may indicate a role for variants in connective tissue-related genes in the pathogenesis of the disease. This scoping review evaluates the evidence supporting this. METHODS: A scoping review was performed using a...

Read the complete abstract on PubMed

Topics

Humans
Rectal Prolapse
Ehlers-Danlos Syndrome
Connective Tissue
Joint Instability

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Marfan Syndrome

Female

Elastin

Collagen

Genetic Predisposition to Disease

Source

Open in PubMed Open full text

Identifiers

PMID: 42765168
DOI: 10.1111/codi.70628
PMCID: PMC13591292

Genes

COLGALT2
EFEMP1
FBLN5
TNXB

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 23 Oct 2026.

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