Association of ACE2 gene polymorphisms with risk of pulmonary arterial hypertension in neonates with congenital heart disease.

doi:10.1186/s12872-026-06368-6

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Article

Association of ACE2 gene polymorphisms with risk of pulmonary arterial hypertension in neonates with congenital heart disease.

BMC cardiovascular disorders - 29 Jul 2026

Chen Youfang, Wang Cuiling, Lin Qingfan, Chen Jin, Lin Li, Luo Shimu, Li Yinshuang, Deng Lifeng

Abstract excerpt

BACKGROUND: Studies have confirmed a correlation between angiotensin-converting enzyme 2 (ACE2) gene polymorphisms and the risk of hypertension; however, its correlation with congenital heart disease (CHD)-related-pulmonary arterial hypertension (PAH) risk in neonates has not been reported. METHODS: The study enrolled 321 Han Chinese neonates, comprising 113 healthy controls and 208 patients with left-to-right...

Read the complete abstract on PubMed

Topics

Humans
Female
Angiotensin-Converting Enzyme 2
Heart Defects, Congenital
Male
Peptidyl-Dipeptidase A

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Polymorphism, Single Nucleotide

Genetic Predisposition to Disease

Infant, Newborn

Risk Factors

Haplotypes

Case-Control Studies

Angiotensin I

Phenotype

China

Peptide Fragments

Genetic Association Studies

Risk Assessment

Source

Open in PubMed Open full text

Identifiers

PMID: 42760528
DOI: 10.1186/s12872-026-06368-6
PMCID: PMC13587371

Genes

ACE2
PAH

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 24 Oct 2026.

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