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Article

Defining metabolic heterogeneity in polyendocrine metabolic ovarian syndrome based on the MTHFR C677T polymorphism: the potential pathway role of homocysteine.

Journal of ovarian research - 9 Sept 2026

Zhao Lidong, Li Peipei, Li Jinhua, Liu Hu, Wang Jinjuan, Qing Limei, Yang Jing, Wang Xiuzhen, Ha Lingxia

Abstract excerpt

BACKGROUND: Polyendocrine Metabolic Ovarian Syndrome (PMOS) is characterized by diverse endocrine and metabolic abnormalities. Patients differ substantially in obesity, insulin resistance, and cardiometabolic risk. Homocysteine (HCY) is associated with insulin resistance and metabolic abnormalities in patients with PMOS, and the methylenetetrahydrofolate reductase (MTHFR) C677T polymorphism is an important...

Read the complete abstract on PubMed

Topics

Humans
Female
Methylenetetrahydrofolate Reductase (NADPH2)
Homocysteine
Metabolic Syndrome
Genotype

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Adult

Polymorphism, Single Nucleotide

Genetic Predisposition to Disease

Retrospective Studies

Source

Open in PubMed Open full text

Identifiers

PMID: 42745328
DOI: 10.1186/s13048-026-02259-8
PMCID: PMC13576099

Genes

MTHFR

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 24 Oct 2026.

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