Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

In sickness and in health: the role of TRAPP and associated proteins in disease.

Traffic (Copenhagen, Denmark) - 1 Aug 2014

Brunet Stephanie, Sacher Michael

Abstract excerpt

Transport protein particle (TRAPP) represents a series of related protein complexes that function in specific stages of inter-organelle traffic. They share a core of subunits that can activate the GTPase Rab1 through a guanine nucleotide exchange factor (GEF) activity and are distinguished by 'accessory' subunits giving each complex its distinct function. The subunits are ubiquitously expressed and, thus,...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Osteochondrodysplasias
Share to Amino Acid Sequence
Share to Genetic Neurodegenerative Diseases

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Molecular Sequence Data

Share to Mutation

Share to Parkinson's Disease Mechanisms and Treatments

Share to Protein Transport

Share to Vesicular Transport Proteins

Source

Identifiers

PMID: 24917561
DOI: 10.1111/tra.12183

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

In sickness and in health: the role of TRAPP and associated proteins in disease.PMID 24917561Read ↗

TRAPPopathies: Severe Multisystem Disorders Caused by Variants in Genes of the Transport Protein Particle (TRAPP) Complexes.Semantic proximity Read ↗

TRAPPopathies: An emerging set of disorders linked to variations in the genes encoding transport protein particle (TRAPP)-associated proteins.Semantic proximity Read ↗

Bi-allelic mutations in TRAPPC2L result in a neurodevelopmental disorder and have an impact on RAB11 in fibroblasts.Semantic proximity Read ↗

The adaptor function of TRAPPC2 in mammalian TRAPPs explains TRAPPC2-associated SEDT and TRAPPC9-associated congenital intellectual disability.Semantic proximity Read ↗

A perspective from transport protein particle: vesicle tether and human diseases.Semantic proximity Read ↗

TRAPPC2L-related disorder: first homozygous protein-truncating variant and further delineation of the phenotype.Semantic proximity Read ↗

A humanized yeast model for studying TRAPP complex mutations; proof-of-concept using variants from an individual with a <i>TRAPPC1</i> -associated neurodevelopmental syndromeSemantic proximity Read ↗

A Humanized Yeast Model for Studying TRAPP Complex Mutations; Proof-of-Concept Using Variants from an Individual with a TRAPPC1-Associated Neurodevelopmental Syndrome.Semantic proximity Read ↗

A homozygous founder mutation in TRAPPC6B associates with a neurodevelopmental disorder characterised by microcephaly, epilepsy and autistic features.Semantic proximity Read ↗

Mutations in TRAPPC12 Manifest in Progressive Childhood Encephalopathy and Golgi Dysfunction.Semantic proximity Read ↗

A novel homozygous variant in TRAPPC2L results in a neurodevelopmental disorder and disrupts TRAPP complex function.Semantic proximity Read ↗

Biallelic variants in TRAPPC10 cause a microcephalic TRAPPopathy disorder in humans and mice.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.