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Article

The adaptor function of TRAPPC2 in mammalian TRAPPs explains TRAPPC2-associated SEDT and TRAPPC9-associated congenital intellectual disability.

PloS one - 1 Jan 2011

Zong Min, Wu Xing-gang, Chan Cecilia W L, Choi Mei Y, Chan Hsiao Chang, Tanner Julian A, Yu Sidney

Abstract excerpt

BACKGROUND: The TRAPP (Transport protein particle) complex is a conserved protein complex functioning at various steps in vesicle transport. Although yeast has three functionally and structurally distinct forms, TRAPPI, II and III, emerging evidence suggests that mammalian TRAPP complex may be di...

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Source

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Identifiers

PMID: 21858081
DOI: 10.1371/journal.pone.0023350
PMCID: PMC3156116

Genes

TRAPPC2
TRAPPC9
TRAPPC8
TRAPPC10

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-21858081-2026-09-04.1. Manifest publication-graph-cohort-2026-09-04.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

Related research

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The adaptor function of TRAPPC2 in mammalian TRAPPs explains TRAPPC2-associated SEDT and TRAPPC9-associated congenital intellectual disability.PMID 21858081Read ↗

TRAPPopathies: Severe Multisystem Disorders Caused by Variants in Genes of the Transport Protein Particle (TRAPP) Complexes.Semantic proximity Read ↗

A novel homozygous variant in TRAPPC2L results in a neurodevelopmental disorder and disrupts TRAPP complex function.Semantic proximity Read ↗

A humanized yeast model for studying TRAPP complex mutations; proof-of-concept using variants from an individual with a <i>TRAPPC1</i> -associated neurodevelopmental syndromeSemantic proximity Read ↗

A Humanized Yeast Model for Studying TRAPP Complex Mutations; Proof-of-Concept Using Variants from an Individual with a TRAPPC1-Associated Neurodevelopmental Syndrome.Semantic proximity Read ↗

TRAPPopathies: An emerging set of disorders linked to variations in the genes encoding transport protein particle (TRAPP)-associated proteins.Semantic proximity Read ↗

In sickness and in health: the role of TRAPP and associated proteins in disease.Semantic proximity Read ↗

Biallelic variants in TRAPPC10 cause a microcephalic TRAPPopathy disorder in humans and mice.Semantic proximity Read ↗

TRAPPC2L-related disorder: first homozygous protein-truncating variant and further delineation of the phenotype.Semantic proximity Read ↗

Bi-allelic mutations in TRAPPC2L result in a neurodevelopmental disorder and have an impact on RAB11 in fibroblasts.Semantic proximity Read ↗

A perspective from transport protein particle: vesicle tether and human diseases.Semantic proximity Read ↗

A homozygous founder mutation in TRAPPC6B associates with a neurodevelopmental disorder characterised by microcephaly, epilepsy and autistic features.Semantic proximity Read ↗

Introducing a novel TRAPPC10 gene variant as a potential cause of developmental delay and intellectual disability in an Iranian family.Semantic proximity Read ↗

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