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TRAPPopathies: An emerging set of disorders linked to variations in the genes encoding transport protein particle (TRAPP)-associated proteins.

Traffic (Copenhagen, Denmark) - 1 Jan 2019

Sacher Michael, Shahrzad Nassim, Kamel Hiba, Milev Miroslav P

Abstract excerpt

The movement of proteins between cellular compartments requires the orchestrated actions of many factors including Rab family GTPases, Soluble NSF Attachment protein REceptors (SNAREs) and so-called tethering factors. One such tethering factor is called TRAnsport Protein Particle (TRAPP), and in humans, TRAPP proteins are distributed into two related complexes called TRAPP II and III. Although thought to act as a...

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PMID: 30152084
DOI: 10.1111/tra.12615

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NSF

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