Article
A bi-directional Mendelian randomization study of sarcopenia-related traits and renal function.
Statistical applications in genetics and molecular biology - 1 Jan 2026
Zhou Xiaoyan, Sun Yan, Hu Yujie, Yang Guoshuai
Abstract excerpt
The association between sarcopenia and renal function has been reported in observational studies; however, the directionality and potential causal nature of these associations remain uncertain. We assessed whether genetically predicted sarcopenia-related traits are associated with renal function and vice versa using bidirectional Mendelian randomization (MR). We conducted a bidirectional two-sample MR analysis...
Read the complete abstract on PubMedTopics
- Humans
- Sarcopenia
- Mendelian Randomization Analysis
- Glomerular Filtration Rate
- Hand Strength
- Genome-Wide Association Study