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Article

Case Report: Pasireotide treatment in neonatal congenital hyperinsulinism due to a homozygous ABCC8 mutation.

Frontiers in endocrinology - 1 Jan 2026

Kurz Calvin, Roeper Marcia, Friesl Lisa, Mayatepek Ertan, Meissner Thomas, Kummer Sebastian, Hoermann Henrike, Welters Alena

Abstract excerpt

Mutations in ABCC8 and KCNJ11 are associated with the most severe and diazoxide-resistant forms of congenital hyperinsulinism (CHI). Somatostatin analogues are commonly used off-label as second-line treatment. While octreotide and lanreotide are the most established options, pasireotide-a second-generation somatostatin analogue with higher affinity for somatostatin receptor subtype 5-has been hypothesized to...

Read the complete abstract on PubMed

Topics

Humans
Infant, Newborn
Congenital Hyperinsulinism
Homozygote
Mutation
Somatostatin

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Sulfonylurea Receptors

Source

Open in PubMed Open full text

Identifiers

PMID: 42723843
DOI: 10.3389/fendo.2026.1873953
PMCID: PMC13557949

Genes

ABCC8
KCNJ11

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 24 Oct 2026.

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