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Article

Sirolimus therapy for congenital hyperinsulinism in an infant with a novel homozygous KCNJ11 mutation.

Journal of pediatric endocrinology & metabolism : JPEM - 26 Jan 2018

Korula Sophy, Chapla Aaron, Priyambada Leena, Mathai Sarah, Simon Anna

Abstract excerpt

BACKGROUND: Congenital hyperinsulinism results in refractory hypoglycemia. If a therapy with diazoxide has been unresponsive this has been treated by subtotal pancreatectomy in the past. This therapeutic option poses an increased risk of developing diabetes at a later stage. There have been a few case reports on the use of sirolimus in such situations in the recent past. CASE PRESENTATION: Our patient was started...

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Share to Congenital Hyperinsulinism
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Potassium Channels, Inwardly Rectifying

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Source

Identifiers

PMID: 29176012
DOI: 10.1515/jpem-2017-0238

Genes

KCNJ11

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026.

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