Article
Association Between CYP2C19 Genotype and P2Y12 Reaction Units in Patients Receiving Clopidogrel After Acute Ischemic Stroke: A Prospective, Observational Study.
Pharmacotherapy - 1 Oct 2026
Stone Rachael M, Smith Annie, Gunter Sonya, Weko Andrew T, Gottschalk Carter, Lee Cheyenne, Ramsey Allison, Weatherspoon Miah Perch, Worrall Bradford B
Abstract excerpt
BACKGROUND: Recurrent stroke accounts for substantial morbidity and mortality worldwide, with up to 25% of ischemic strokes occurring in patients with prior strokes. Dual antiplatelet therapy (DAPT) with aspirin and clopidogrel is standard for secondary prevention after minor acute ischemic stroke (AIS) or high-risk transient ischemic attack (TIA). However, clopidogrel efficacy is reduced in carriers of...
Read the complete abstract on PubMedTopics
- Cytochrome P-450 CYP2C19
- Humans
- Clopidogrel
- Ischemic Stroke
- Prospective Studies