CYP2C19 Genetic Variability, ADP-Induced Whole-Blood Platelet Aggregation, and Clopidogrel Response in an Exploratory Retrospective Cohort of Acute Ischemic Stroke.

doi:10.1177/10760296261486174

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Article

CYP2C19 Genetic Variability, ADP-Induced Whole-Blood Platelet Aggregation, and Clopidogrel Response in an Exploratory Retrospective Cohort of Acute Ischemic Stroke.

Clinical and applied thrombosis/hemostasis : official journal of the International Academy of Clinical and Applied Thrombosis/Hemostasis - 1 Jan 2026

Ravichandran Soumya, Phan Cattien, Meyer Dawn M, Eghbalnejadmofrad Amirmohammad, Akhavan-Sigari Amirhossein, Jazayeri Seyed Behnam, Batarseh Sanad, D'Souza Marissa, Hu Tiffany, Hailey Lovella, Agrawal Kunal, Modir Royya F, Hemmen Thomas, Meyer Brett C, Bavarsad Shahripour Reza

Abstract excerpt

BackgroundPatient response to clopidogrel varies due to CYP2C19 genetic polymorphisms. Impaired metabolism has been linked to an increased risk of recurrent ischemic events. The purpose of this study was to examine CYP2C19 phenotypes and the impact on ADP aggregation in whole blood platelet aggregometry (WBPA) in patients with acute ischemic stroke (AIS).MethodsPatients with AIS or transient ischemic attack (TIA)...

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Topics

Humans
Cytochrome P-450 CYP2C19
Clopidogrel

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Platelet Aggregation

Female

Retrospective Studies

Male

Ischemic Stroke

Adenosine Diphosphate

Aged

Platelet Aggregation Inhibitors

Middle Aged

Genetic Variation

Source

Open in PubMed Open full text

Identifiers

PMID: 42678292
DOI: 10.1177/10760296261486174
PMCID: PMC13535049

Genes

CYP2C19

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 25 Oct 2026.

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