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Article

The Frequency of CYP2C19 Loss-of-Function Variants in Patients with Non-Cardioembolic Ischemic Stroke or Transient Ischemic Attack in the Dutch Population.

Cerebrovascular diseases (Basel, Switzerland) - 1 Jan 2023

van den Heuvel Lotte, Vermeer Henricus J, Kerkhoff Henk, Roozenbeek Bob, Zock Elles

Abstract excerpt

INTRODUCTION: The CYP2C19 enzyme converts clopidogrel into an active metabolite. Carriers of CYP2C19 loss-of-function (LOF) variants with a history of ischemic stroke or transient ischemic attack (TIA) using clopidogrel may have a higher risk of recurrent stroke. To study the implications of genetic CYP2C19 heterogeneity in treatment of cerebral ischemia, knowledge about the prevalence of CYP2C19 LOF variants...

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Identifiers

PMID: 36948156
DOI: 10.1159/000529892

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