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Epidermal growth factor receptor (EGFR) atypical mutations in non-small-cell lung cancer (NSCLC): 'Where the streets have no name'.

Critical reviews in oncology/hematology - 1 Jul 2026

Spitaleri Gianluca, Trillo Aliaga Pamela, Mariani Gianluca Alessio, Attili Ilaria, Del Signore Ester, Corvaja Carla, Napoli Valerio Maria, Cavallone Matteo, Etessami Julian David, Zhan Yinxiu, Passaro Antonio, de Marinis Filippo

Abstract excerpt

Atypical Epidermal Growth Factor Receptor (EGFR) mutations in non-small-cell lung cancer (NSCLC) account for approximately 12% of all EGFR alterations. In contrast to classical mutations (exon 19 deletions and exon 21 L858R) and exon 20 insertions, for which therapeutic strategies have significantly evolved, relatively little progress has been achieved in the management of patients with atypical EGFR-mutated...

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PMID: 41967619
DOI: 10.1016/j.critrevonc.2026.105327

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EGFR

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