Harnessing pain heterogeneity and RNA transcriptome to identify blood‐based pain biomarkers: a novel correlational study design and bioinformatics approach in a graded chronic constriction injury model

Abstract excerpt

A quantitative, peripherally accessible biomarker for neuropathic pain has great potential to improve clinical outcomes. Based on the premise that peripheral and central immunity contribute to neuropathic pain mechanisms, we hypothesized that biomarkers could be identified from the whole blood of adult male rats, by integrating graded chronic constriction injury (CCI), ipsilateral lumbar dorsal quadrant (iLDQ)...