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Article

Alzheimer disease and lichen planus: A Mendelian randomization analysis.

Medicine - 4 Sept 2026

Huang Wenya, Xiao Liyuan

Abstract excerpt

Observational studies suggest an association between lichen planus (LP) and Alzheimer disease (AD), but causality remains unclear due to confounding and reverse causation. In this study, we conducted a bidirectional two-sample Mendelian randomization (MR) analysis using Integrative Epidemiology Unit OpenGWAS database for LP (ID: finn-b-L12_LICHENPLANUS) and AD (ID: ebi-a-GCST90012877). The inverse-variance...

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Topics

Alzheimer Disease
Humans
Mendelian Randomization Analysis
Lichen Planus
Genetic Predisposition to Disease
Polymorphism, Single Nucleotide

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Source

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Identifiers

PMID: 42700087
DOI: 10.1097/MD.0000000000050313
PMCID: PMC13549574

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