Genomic and structural analysis of dacB variants associated with cephalosporin resistance in Pseudomonas aeruginosa.

doi:10.1038/s41598-026-64707-1

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Article

Genomic and structural analysis of dacB variants associated with cephalosporin resistance in Pseudomonas aeruginosa.

Scientific reports - 4 Aug 2026

Mathpal Shalini, Karthik Maruthan, Joshi Tushar, Ramesh Vishnukumar, Walia Kamini, Gunasekaran Karthik, Veeraraghavan Balaji, Ramaiah Sudha, Anbarasu Anand

Abstract excerpt

The rise of resistance to fourth-generation cephalosporin in Pseudomonas aeruginosa (P. aeruginosa) is a global concern. The resistance is largely driven by variants of chromosomally encoded AmpC β-lactamase, known as Pseudomonas-derived cephalosporinase (PDC), which arise from the mutations in the ampC gene. In addition, alteration in dacB, which encode the penicillin-binding protein 4 (PBP4), can lead to the...

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Topics

Pseudomonas aeruginosa
Cephalosporin Resistance
Penicillin-Binding Proteins
Polymorphism, Single Nucleotide
Bacterial Proteins

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Cephalosporins

Anti-Bacterial Agents

Microbial Sensitivity Tests

Mutation

Molecular Dynamics Simulation

Molecular Docking Simulation

Whole Genome Sequencing

Humans

beta-Lactamases

Source

Open in PubMed Open full text

Identifiers

PMID: 42686894
DOI: 10.1038/s41598-026-64707-1
PMCID: PMC13538626

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