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Article

Genetically defined systemic autoinflammatory diseases in pediatric patients with Behçet's disease.

Frontiers in immunology - 1 Jan 2026

Zheng Shaoling, Lee Pui Y, Zhou Qing, Han Xu, Huang Xuechan, Huang Yukai, Chen Jiajun, Zheng Chun, Fang Xiaolin, Yu Jianhua, Wang Aiwu, Pan Xia, Yu Xiaomin, Li Tianwang

Abstract excerpt

Objectives: The aim of this study was to characterize the genetic basis of Behçet's disease (BD) and mimics in a pediatric cohort. Methods: We retrospectively studied 34 patients of pediatric BD and mimics who underwent whole-exome sequencing (WES) in our center from 2020 to 2025. Clinical characteristics and laboratory parameters of the patients with or without genetically defined systemic autoinflammatory...

Read the complete abstract on PubMed

Topics

Humans
Behcet Syndrome
Female
Male
Child
Adolescent

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Retrospective Studies

Hereditary Autoinflammatory Diseases

Genetic Predisposition to Disease

Exome Sequencing

Child, Preschool

Cytokines

Source

Open in PubMed Open full text

Identifiers

PMID: 42682521
DOI: 10.3389/fimmu.2026.1897406
PMCID: PMC13529686

Genes

GATA2
RELA
TNFAIP3

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 25 Oct 2026.

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