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Article

Utility of RNA Sequencing and Immunohistochemistry for NTRK Fusion in Thyroid Carcinoma.

Anticancer research - 1 Sept 2026

Toda Soji, Kasajima Rika, Okubo Yoichiro, Saito Nao, Kadoya Mei, Matsui A I, Sato Shinya, Yamazaki Haruhiko, Suganuma Nobuyasu, Masudo Katsuhiko, Saito Aya, Hoshino Daisuke

Abstract excerpt

BACKGROUND/AIM: Neurotrophic tropomyosin receptor kinase (NTRK) fusion is one of the druggable driver genes of thyroid cancer, which is confirmed in surgical specimens. However, there is a risk that certain fusion patterns may not be detected using gene panel testing. This study aimed to identify patients harboring NTRK fusion who might be overlooked by panel testing. PATIENTS AND METHODS: Two patient groups were...

Read the complete abstract on PubMed

Topics

Humans
Thyroid Neoplasms
Female
Male
Immunohistochemistry
Middle Aged

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Oncogene Proteins, Fusion

Receptor, trkA

Adult

Sequence Analysis, RNA

Aged

Mutation

Proto-Oncogene Proteins B-raf

Receptor, trkC

Thyroid Cancer, Papillary

Biomarkers, Tumor

Source

Identifiers

PMID: 42674723
DOI: 10.21873/anticanres.18343

Genes

BRAF
NTRK3
NTRK1
ETV6
RET
SQSTM1
TFG

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 23 Oct 2026.

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