Structure-function analysis of the FCRL5-IgG1 Fc complex reveals an unappreciated pathway for B cell modulation by Fc-attenuated IgG.

doi:10.1126/sciadv.aei1233

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Article

Structure-function analysis of the FCRL5-IgG1 Fc complex reveals an unappreciated pathway for B cell modulation by Fc-attenuated IgG.

Science advances - 28 Aug 2026

Herpers Bart M, Guo Mo, Ko Sanghwan, Delidakis George, Kim Jin Eyun, Lee Chang-Han, Gadallah Mohamed I, Brodbelt Jennifer S, Zhang Y Jessie, Georgiou George

Abstract excerpt

The Fc region of therapeutic IgG antibodies is often engineered to remove or "silence" Fc effector functions, but it remains unclear whether these mutations eliminate all Fc-mediated effector activity. Human Fc receptor-like 5 (FCRL5/FcRH5) is a low-affinity IgG Fc receptor expressed on B cells and is an actively pursued antibody target in multiple myeloma. Here, we show that common Fc function-silencing...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 42664341
DOI: 10.1126/sciadv.aei1233
PMCID: PMC13524021

Genes

FCRL5

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026.