Metabolic, viral, and immune phenotypes in long COVID.

doi:10.3389/fendo.2026.1899115

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Metabolic, viral, and immune phenotypes in long COVID.

Frontiers in endocrinology - 1 Jan 2026

Emery Ivette F, Sahagun Seynt Jiro, Zunica Elizabeth R M, Axelrod Christopher, Beyl Robbie A, Cho Eunhan, Spielmann Guillaume, Costa Samantha, DeKay Joanne T, Chlebek Carolyn, Amano Shinya, Stevens Katherine, Scherer Philipp E, Bu Dawei, Javidan Aida, Finlin Brian S, Zhang Xiaohua D, Nikolajczyk Barbara, Blish C Catherine, Bramante Carolyn, McLaughlin Tracey, DeLine-Caballero Soneida, Ratnasiri Kalani, Mangalanathan Uma, Li Jonathan Z, Leeman Brooke M, Edelstein Gregory, Karlson Elizabeth W, Kirwan John P, Kern Philip A, Ryzhov Sergei, Rosen Clifford J

Abstract excerpt

Context: Long COVID is characterized by persistent symptoms ≥ 3 months after acute SARS-CoV-2 infection. To date, the underlying pathophysiology is unclear. Objective: To characterize the immune and metabolic features of Long COVID and the potential role of viral persistence in adipose tissue. Design: Case-control, cross-sectional study under the RECOVER initiative. Setting: Maine, Louisiana, and Kentucky....

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Identifiers

PMID: 42656834
DOI: 10.3389/fendo.2026.1899115
PMCID: PMC13508033

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