Precision Symptom Phenotyping Identifies Early Clinical and Proteomic Predictors of Distinct COVID-19 Sequelae.

doi:10.1093/infdis/jiae318

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Article

Precision Symptom Phenotyping Identifies Early Clinical and Proteomic Predictors of Distinct COVID-19 Sequelae.

The Journal of infectious diseases - 30 Jul 2025

Epsi Nusrat J, Chenoweth Josh G, Blair Paul W, Lindholm David A, Ganesan Anuradha, Lalani Tahaniyat, Smith Alfred, Mody Rupal M, Jones Milissa U, Colombo Rhonda E, Colombo Christopher J, Schofield Christina, Ewers Evan C, Larson Derek T, Berjohn Catherine M, Maves Ryan C, Fries Anthony C, Chang David, Wyatt Andrew, Scher Ann I, Byrne Celia, Rusiecki Jennifer, Saunders David L, Livezey Jeffrey, Malloy Allison, Bazan Samantha, Maldonado Carlos, Edwards Margaret Sanchez, Mende Katrin, Simons Mark P, O'Connell Robert J, Tribble David R, Agan Brian K, Burgess Timothy H, Pollett Simon D, Richard Stephanie A

Abstract excerpt

BACKGROUND: Post-COVID conditions (PCC) are difficult to characterize, diagnose, predict, and treat due to overlapping symptoms and poorly understood pathology. Identifying inflammatory profiles may improve clinical prognostication and trial endpoints. METHODS: This analysis included 1988 SARS-CoV-2 positive U.S. Military Health System beneficiaries who had quantitative post-COVID symptom scores. Among...

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Identifiers

PMID: 38916431
DOI: 10.1093/infdis/jiae318
PMCID: PMC12308661

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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