Genome-Wide Association of Genetic Variants with Intestinal Cholesterol Absorption Markers in a European Population.

doi:10.3390/nu18162679

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Article

Genome-Wide Association of Genetic Variants with Intestinal Cholesterol Absorption Markers in a European Population.

Nutrients - 16 Aug 2026

Mokhtar Fatma B A, Nuwaylati Dena A, Plat Jogchum, Coort Susan L M, Popeijus Herman E, Kleber Marcus E, Lütjohann Dieter, Mensink Ronald P

Abstract excerpt

Background: Interindividual variability in intestinal cholesterol absorption contributes to differences in serum lipid concentrations and cardiovascular risk. Total cholesterol (TC)-standardized campesterol and sitosterol levels are established markers of cholesterol absorption. However, genetic variants in Europeans associated with these markers remain incompletely characterized. Methods: A genome-wide...