Artemisia annua and A. afra Teas, Artemisinin, and Dihydroartemisinin Differentially Regulate ROS and Fibrosis-Associated Phenotypes in Human Dermal Fibroblasts.

doi:10.3390/molecules31162745

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Article

Artemisia annua and A. afra Teas, Artemisinin, and Dihydroartemisinin Differentially Regulate ROS and Fibrosis-Associated Phenotypes in Human Dermal Fibroblasts.

Molecules (Basel, Switzerland) - 7 Aug 2026

Isife Samuel, Bush Trevor, Medasani Isha, Towler Melissa, Weathers Pamela

Abstract excerpt

Fibrosis is driven by persistent fibroblast activation, oxidative stress, myofibroblast differentiation, and extracellular matrix remodeling, yet available antifibrotic therapies remain limited. This study evaluated whether artemisinin (ART), dihydroartemisinin (DHA), and traditional tea infusions of Artemisia annua and A. afra differentially regulate fibrosis-associated responses in human dermal fibroblasts....

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 42653828
DOI: 10.3390/molecules31162745
PMCID: PMC13515305

Genes

ACTA2
COL1A1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026.