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Article

LMTK3 expression in breast cancer: association with tumor phenotype and clinical outcome.

Breast cancer research and treatment - 1 Apr 2012

Stebbing Justin, Filipovic Aleksandra, Ellis Ian O, Green Andrew R, D'Silva Tanya Rapoz, Lenz Heinz-Josef, Coombes R Charles, Wang Tingting, Lee Soo-Chin, Giamas Georgios

Abstract excerpt

Interactions between kinases and the estrogen receptor α (ERα) are thought to be a critical signaling pathway in the majority of human breast cancers. We have recently identified a previously uncharacterized molecule, lemur tyrosine kinase-3 (LMTK3) as a prognostic and predictive oncogenic ERα regulator with a central role in endocrine resistance. Unusually this protein has undergone Darwinian positive selection...

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Identifiers

PMID: 21671015
DOI: 10.1007/s10549-011-1622-z

Genes

LMTK3

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LMTK3 expression in breast cancer: association with tumor phenotype and clinical outcome.PMID 21671015Read ↗

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