Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Subfunctionalization influences the expansion of bacterial multidrug antibiotic resistance.

BMC genomics - 30 Oct 2017

Perrin Elena, Fondi Marco, Bosi Emanuele, Mengoni Alessio, Buroni Silvia, Scoffone Viola Camilla, Valvano Miguel, Fani Renato

Abstract excerpt

BACKGROUND: Antibiotic resistance is a major problem for human health. Multidrug resistance efflux pumps, especially those of the Resistance-Nodulation-Cell Division (RND) family, are major contributors to high-level antibiotic resistance in Gram-negative bacteria. Most bacterial genomes contain several copies of the different classes of multidrug resistance efflux pumps. Gene duplication and gain of function by...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Bacteria
Share to Bacterial Physiological Phenomena

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Burkholderia

Share to Drug Resistance, Multiple, Bacterial

Share to Gene Order

Share to Genome, Bacterial

Share to Microbial Sensitivity Tests

Share to Operon

Source

Open in PubMed Open full text

Identifiers

PMID: 29084524
DOI: 10.1186/s12864-017-4222-4
PMCID: PMC5663151

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Subfunctionalization influences the expansion of bacterial multidrug antibiotic resistance.PMID 29084524Read ↗

Ever-Adapting RND Efflux Pumps in Gram-Negative Multidrug-Resistant Pathogens: A Race against TimeSemantic proximity Read ↗

Resistance in gram-negative bacilli: the emergence of RND efflux pumpsSemantic proximity Read ↗

Eﬄux pump-mediated drug resistance in BurkholderiaSemantic proximity Read ↗

RND Efflux Pump Induction: A Crucial Network Unveiling Adaptive Antibiotic Resistance Mechanisms of Gram-Negative BacteriaSemantic proximity Read ↗

Tripartite efflux pumps of the RND superfamily: what did we learn from computational studies?Semantic proximity Read ↗

Structural and functional diversity of Resistance-Nodulation-Division (RND) efflux pump transporters with implications for antimicrobial resistanceSemantic proximity Read ↗

RND multidrug efflux transporters: similar appearances, diverse actionsSemantic proximity Read ↗

The Challenge of Efflux-Mediated Antibiotic Resistance in Gram-Negative BacteriaSemantic proximity Read ↗

Raising the stakes: Loss of efflux-pump regulation decreases meropenem susceptibility in <i>Burkholderia pseudomallei</i>Semantic proximity Read ↗

Bacterial Multidrug Efflux TransportersSemantic proximity Read ↗

Efflux pump-mediated resistance to new beta lactam antibiotics in multidrug-resistant gram-negative bacteriaSemantic proximity Read ↗

Drug resistance and physiological roles of RND multidrug efflux pumps in Salmonella enterica, Escherichia coli and Pseudomonas aeruginosaSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.