Whole-genome and pan-genome analyses reveal genomic differences among nontypeable Haemophilus influenzae isolates from bronchiectasis, community-acquired pneumonia, and chronic obstructive pulmonary disease.

Abstract excerpt

Background: Nontypeable Haemophilus influenzae (NTHi) is a major bacterial pathogen in both acute and chronic respiratory diseases, yet the genomic basis underlying its association with different clinical phenotypes remains incompletely understood. Methods: We performed whole-genome sequencing and comparative genomic analysis of 27 NTHi isolates, including strains derived from patients with bronchiectasis (n =...

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