Prevalence of uncommon epidermal growth factor receptor ( EGFR ) Mutations in Non-Small Cell Lung Carcinoma (NSCLC): A tertiary cancer care center experience.

Abstract excerpt

BACKGROUND: Non-Small Cell Lung Carcinoma (NSCLC) is frequently associated with driver mutations in the epidermal growth factor receptor (EGFR) gene. Activating EGFR mutations occur in approximately 14-38% of NSCLC cases, with common mutations-exon 19 deletions and exon 21 L858R-accounting for nearly 90%. Uncommon mutations, including G719X, S768I, L861Q, and exon 20 insertions (Ins20), excluding T790M, comprise...

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