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Article

Decoding the Clinical and Molecular Signatures of EGFR Common, Compound, and Uncommon Mutations in NSCLC: A Brief Report.

Journal of thoracic oncology : official publication of the International Association for the Study of Lung Cancer - 1 Apr 2025

Tavernari Daniele, Borgeaud Maxime, Liu Ximeng, Parikh Kaushal, Le Xiuning, Ciriello Giovanni, Addeo Alfredo

Abstract excerpt

INTRODUCTION: EGFR mutations are key oncogenic drivers in lung adenocarcinoma (LUAD), predominantly affecting Asian, nonsmoking, and female populations. Although common mutations, such as exon 19 deletions and L858R, respond well to tyrosine kinase inhibitors (TKIs), uncommon EGFR mutations and compound variants exhibit variable treatment responses. This study aims to compare clinical characteristics and...

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Identifiers

PMID: 39694414
DOI: 10.1016/j.jtho.2024.12.012

Genes

EGFR
KRAS
TP53

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026.

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