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Article

Novel clinical phenotype-based stratification identifies distinct immunopathological and ultrasonographic signatures in Sjögren's disease.

Rheumatology (Oxford, England) - 1 Sept 2026

Xu Nan, Cheng Lian, Ding Yimin, Tang Yiping, Tan Wei, Chen Jiwei, Fang Yuxuan, Chen Hongyi, Shen Jiacheng, Wang Zheng, Li Guoqing

Abstract excerpt

OBJECTIVES: To characterize glandular immune composition and structural involvement across clinically defined Sjögren's disease (SjD) subgroups-B cell active disease with low symptom burden (BALS), high systemic activity (HSA) and low systemic activity with high symptom burden (LSAHS)-by integrating quantitative immunohistochemistry (IHC) with salivary gland ultrasonography (SGUS) and shear wave elastography...

Read the complete abstract on PubMed

Topics

Humans
Sjogren's Syndrome
Female
Middle Aged
Elasticity Imaging Techniques
Male

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Phenotype

Salivary Glands

Adult

B-Lymphocytes

Aged

T-Lymphocytes

Immunohistochemistry

Ultrasonography

Leukocyte Common Antigens

Severity of Illness Index

Source

Identifiers

PMID: 42605053
DOI: 10.1093/rheumatology/keag423

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 25 Oct 2026.

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