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Article

Genomic constraint and hypervariability correlate with fitness effects in elite tetraploid potato breeding material.

PLoS genetics - 1 Aug 2026

Aalborg Trine, Ding Zihui, Wu Yaoyao, Sverrisdóttir Elsa, Nielsen Kåre Lehmann, Ramstein Guillaume P

Abstract excerpt

Tetraploid potato is the most important vegetable food crop in the world. However, genetic gains from modern breeding efforts have been limited due to tetrasomic inheritance, the accumulation of deleterious mutations during domestication, and subsequent clonal propagation during modern breeding. In this study, we analyzed previously identified evolutionarily constrained genomic regions in the potato genome...

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PMID: 42579721
DOI: 10.1371/journal.pgen.1012271
PMCID: PMC13492815

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