A Shape Analysis Algorithm Quantifies Spatial Morphology and Context of 2D to 3D Cell Culture for Novel Quantitation of Phenotypes.

Abstract excerpt

Numerous studies have shown that the morphological phenotype of a cell or organoid correlates with its susceptibility to anti-cancer agents. However, traditional methods of measuring phenotype rely on spatial metrics such as area, volume, perimeter, and signal intensity, which work but are limited. These approaches cannot measure many crucial features of spatial context, such as chirality, a property of left- and...

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