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Article

Association of methylenetetrahydrofolate reductase C677T polymorphism with lacunar infarction: A systematic review and meta-analysis.

Medicine - 7 Aug 2026

Gao Qing, Kong Fanxin, Lin Songjun, Pi Min, Qin Xiude, Zheng Haotao

Abstract excerpt

BACKGROUND: The association between the methylenetetrahydrofolate reductase (MTHFR) C677T polymorphism and lacunar infarction (LI) remains inconclusive. METHODS: The literature retrieval encompassed PubMed, EMBASE, Cochrane Library, China National Knowledge Infrastructure, and Wanfang (inception...

Topics

Humans
Methylenetetrahydrofolate Reductase (NADPH2)
Stroke, Lacunar
Genetic Predisposition to Disease
Polymorphism, Single Nucleotide
Genotype
Case-Control Studies
Asian People
Odds Ratio

Source

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Open in PubMed Open full text

Identifiers

PMID: 42566580
DOI: 10.1097/MD.0000000000050084
PMCID: PMC13456852

Genes

MTHFR

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-42566580-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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Association of methylenetetrahydrofolate reductase C677T polymorphism with lacunar infarction: A systematic review and meta-analysis.PMID 42566580Read ↗

Association of C677T polymorphism in the methylenetetrahydrofolate reductase gene (MTHFR gene) with ischemic stroke: a meta-analysis.Semantic proximity Read ↗

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