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Article

Neurocognitive and neuropsychiatric presentation identifies a higher-risk clinical phenotype in IDH-wildtype glioblastoma: A retrospective cohort study.

Clinical neurology and neurosurgery - 1 Nov 2026

Donnini Flavio, Pastina Pierpaolo, Battaglia Giuseppe, Rubino Giovanni, Chibbaro Salvatore, Cerase Alfonso, Minniti Giuseppe, Tini Paolo

Abstract excerpt

OBJECTIVE: In IDH-wildtype glioblastoma, prognosis is conventionally interpreted through established molecular, clinical, surgical and anatomical factors, whereas the prognostic meaning of the mode of onset is less defined. We hypothesized that neurocognitive/neuropsychiatric presentation identifies an adverse clinical phenotype, potentially reflecting diagnostic delay and/or early disruption of distributed...

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Identifiers

PMID: 42556067
DOI: 10.1016/j.clineuro.2026.109602

Genes

MGMT

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 3 Sept 2026.

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