Article
CCDC141 Mutations in Idiopathic Hypogonadotropic Hypogonadism.
The Journal of clinical endocrinology and metabolism - 1 Jun 2017
Turan Ihsan, Hutchins B Ian, Hacihamdioglu Bulent, Kotan L Damla, Gurbuz Fatih, Ulubay Ayca, Mengen Eda, Yuksel Bilgin, Wray Susan, Topaloglu A Kemal
Abstract excerpt
Context: Gonadotropin-releasing hormone neurons originate outside the central nervous system in the olfactory placode and migrate into the central nervous system, becoming integral components of the hypothalamic-pituitary-gonadal axis. Failure of this migration can lead to idiopathic hypogonadotropic hypogonadism (IHH)/Kallmann syndrome (KS). We have previously shown that CCDC141 knockdown leads to impaired...
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