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Article

A functional polymorphism in RGS6 modulates the risk of bladder cancer.

Cancer research - 15 Sept 2004

Berman David M, Wang Yunfei, Liu Zhengyu, Dong Qiong, Burke Lorri-Anne, Liotta Lance A, Fisher Rory, Wu Xifeng

Abstract excerpt

RGS proteins negatively regulate heterotrimeric G protein signaling. Recent reports have shown that RGS proteins modulate neuronal, cardiovascular, and lymphocytic activity, yet their role in carcinogenesis has not been explored. In an epidemiologic study of 477 bladder cancer patients and 446 matched controls, three noncoding single-nucleotide polymorphisms (SNPs) in RGS2 and RGS6 were each associated with a...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 15375002
DOI: 10.1158/0008-5472.CAN-04-1916

Genes

RGS6
RGS2

Provenance

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