99mTc-FAPI-YQ3 SPECT/CT for characterizing FAPI uptake phenotypes and metabolic-stromal heterogeneity in advanced differentiated thyroid carcinoma: a prospective single-center imaging-radiomics study.

Abstract excerpt

Objective: Advanced and metastatic differentiated thyroid carcinoma (DTC), particularly radioactive iodine (RAI)-refractory disease, is characterized by spatially heterogeneous tumor biology and limited therapeutic options. Fibroblast activation protein inhibitor (FAPI)-targeted imaging may provide noninvasive imaging correlates of stromal-related tumor phenotypes; however, tracer uptake should not be interpreted...

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