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Article

Validation of the International Medullary Thyroid Carcinoma Grading System in Patients with Distant Metastases.

Thyroid : official journal of the American Thyroid Association - 1 Nov 2025

Porcelli Tommaso, Moog Sophie, Bani Mohamed-Amine, Hadoux Julien, Bruzzese Dario, Salvatore Domenico, Deandreis Désirée, Schlumberger Martin, Hartl Dana, Breuskin Ingrid, Nariman Saba Khazen, Baudin Eric, Al Ghuzlan Abir, Lamartina Livia

Abstract excerpt

Background: The International Medullary Thyroid Carcinoma Grading System (IMTCGS) is a two-tier score that classifies high-grade medullary thyroid carcinoma (MTC) by the presence of at least one of the following features: mitotic index ≥5/2 mm2, Ki-67 proliferation index ≥5%, or tumor necrosis. Cases lacking all three features are classified as low-grade. This study aimed to validate the prognostic role of the...

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Aged, 80 and over
Carcinoma, Neuroendocrine
Ki-67 Antigen
Mitotic Index

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Neoplasm Grading

Neoplasm Metastasis

Thyroid Neoplasms

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PMID: 41153085
DOI: 10.1177/10507256251388028

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RET

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