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Article

Diffuse hemispheric glioma, H3 G34-mutant, in Simpson-Golabi-Behmel syndrome: the first reported case.

Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery - 28 Jul 2026

Amisaki Hidefumi, Kambe Atsushi, Yoshioka Hiroki, Nagao Yuichiro, Tabuchi Sadaharu, Kurosaki Masamichi

Abstract excerpt

Simpson-Golabi-Behmel syndrome (SGBS) is an overgrowth syndrome associated with an increased risk of certain malignancies; however, gliomas have not previously been reported in patients with SGBS. Loss-of-function variants in glypican-3 (GPC3) represent the primary molecular mechanism underlying SGBS-related overgrowth and tumorigenesis, although their relationship with gliomas remains unclear. We report a case...

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Identifiers

PMID: 42517967
DOI: 10.1007/s00381-026-07417-3

Genes

GPC3

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

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