Synonymous codon-optimized multiplex qPCR for simultaneous detection of Helicobacter pylori and precise drug resistance profiling in infected individuals.

Abstract excerpt

Antibiotic-resistant Helicobacter pylori (H. pylori) represents a significant global challenge to the efficacy of eradication therapies, underscoring the urgent need for rapid and precise pretreatment resistance profiling. Traditional genotyping assays frequently neglect synonymous mutations, resulting in false-negative results and reduced diagnostic accuracy. In this study, we developed a single-tube, synonymous...

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